Why Was Trilostane Taken Off The Market a medication used to address Cushing’s syndrome, a condition characterized by the excessive production of steroids by the adrenal glands, was removed from the U.S. human market in April 1994. Cushing’s syndrome results from an overproduction of steroids, which can lead to various health issues. Trilostane was utilized to reduce the production of steroids by the adrenal glands.
What Type of Drug is Trilostane?
Trilostane is classified as a steroidogenesis inhibitor. Specifically, it inhibits the action of 3β-hydroxysteroid dehydrogenase (3β-HSD).
What is Vetoryl, and How Does It Differ from Trilostane?
Vetoryl is a medication in capsule form containing an adrenosuppressant drug used to treat hyperadrenocorticism (Cushing’s disease) in dogs. While Trilostane and Vetoryl serve similar purposes, Vetoryl is designed for veterinary use in dogs, while Trilostane was originally intended for human use.
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Is Trilostane a Steroid?
Yes, Trilostane is a synthetic steroid that selectively inhibits the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) in the adrenal cortex.
What Drugs Interact with Vetoryl?
When administering Trilostane (Vetoryl) to dogs, it should be used cautiously in conjunction with certain other drugs. These include ACE inhibitors (e.g., benazepril or enalapril), aminoglutethimide, ketoconazole, mitotane, potassium-sparing diuretics (such as spironolactone), and potassium supplements.
Can You Stop Vetoryl Treatment?
In most cases, dogs requiring Vetoryl treatment will need it for the rest of their lives. Discontinuing treatment without the guidance of a veterinarian is generally not recommended.
Is Trilostane Hazardous?
Trilostane may cause skin irritation and could be harmful if inhaled, ingested, or absorbed through the skin. Care should be taken when handling it.
Is Trilostane a Hazardous Drug?
Hazardous drugs, including Trilostane, are those that meet specific criteria established by organizations like the National Institute for Occupational Health (NIOSH). These drugs can pose risks to individuals handling them. Examples of hazardous drugs include methimazole, trilostane, chemotherapeutic agents, hormones, and fluconazole, among others.
What Are the Symptoms of an Allergic Reaction to Aleve?
An allergic reaction to Aleve may manifest with symptoms such as hives, facial swelling, wheezing (asthma), shock, skin redness, rash, or blisters. If an allergic reaction occurs, discontinue use and seek immediate medical assistance. It’s essential not to take Aleve if you have previously experienced an allergic reaction to Aleve or any other pain reliever/fever reducer.
Does Aleve Contain Acetaminophen?
No, Aleve does not contain acetaminophen. It is important not to take Aleve with acetaminophen or any other pain reliever/fever reducer unless specifically advised by a doctor. If you’ve had an allergic reaction to Aleve or any similar medication in the past, avoid taking it.